CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
应用类型
FC (QC tested), FUNC
免疫原
Human peripheral blood lymphocytes
来源宿主
小鼠
反应性
Pig, Human
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.